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Pan-Acute Lymphoblastic Leukemia
St. Jude Cloud
Data Resource:  St. Jude Cloud
Point of Contact:  
Clay McLeod ; Jinghui Zhang,  
Project

About This Dataset
The Pan-Acute Lymphoblastic Leukemia (PanALL) dataset comprises cases of B-progenitor and T-lineage ALL encompassing the spectrum of ALL subtypes across the age continuum. Samples sequenced were obtained from multiple sites, centers and cooperative groups including St Jude Children's Research Hospital, The Children's Oncology Group, The Alliance-Cancer and Leukemia Group B, City of Hope National Medical Center, the Eastern Cooperative Oncology Group, MD Anderson Cancer Center, Northern Italy Leukemia Group, Princess Margaret Cancer Center, The Southwestern Oncology group, and UKALL.
Core Data Elements
Number of Cases
735
Case Sex
Female (310); Male (425)
Case Age At Diagnosis
0 to 4 years (204); 5 to 9 years (150); 10 to 14 years (193); 15 to 19 years (152); 20 to 24 years (31); 25 to 29 years (4); 30 to 34 years (1)
Case Race
White (1); Not Reported (734)
Case Ethnicity
Not Reported (735)
Case Disease Diagnosis
B-cell Acute Lymphoblastic Leukemia, BCR-ABL1 (28); B-cell Acute Lymphoblastic Leukemia, BCR-ABL1 like (139); B-cell Acute Lymphoblastic Leukemia, CRLF2 rearrangement (7); B-cell Acute Lymphoblastic Leukemia, Dicentric (3); B-cell Acute Lymphoblastic Leukemia, Down Syndrome (3); B-cell Acute Lymphoblastic Leukemia, DUX4-IGH (44); B-cell Acute Lymphoblastic Leukemia, ETV6-RUNX1 (48); B-cell Acute Lymphoblastic Leukemia, ETV6-RUNX1 like (24); B-cell Acute Lymphoblastic Leukemia, Hyperdiploidy (153); B-cell Acute Lymphoblastic Leukemia, Hypodiploidy (25); B-cell Acute Lymphoblastic Leukemia, iAMP21 (45); B-cell Acute Lymphoblastic Leukemia, IKZF1 N159Y (3); B-cell Acute Lymphoblastic Leukemia, KMT2A rearrangement (14); B-cell Acute Lymphoblastic Leukemia, KMT2A rearrangement like (1); B-cell Acute Lymphoblastic Leukemia, MEF2D rearrangement (22); B-cell Acute Lymphoblastic Leukemia, NOS (35); B-cell Acute Lymphoblastic Leukemia, NUTM1 rearrangement (6); B-cell Acute Lymphoblastic Leukemia, PAX5 alteration (52); B-cell Acute Lymphoblastic Leukemia, PAX5 P80R (13); B-cell Acute Lymphoblastic Leukemia, TCF3-PBX1 (17); B-cell Acute Lymphoblastic Leukemia, ZEB2 alteration and CEBPE rearrangement (1); B-cell Acute Lymphoblastic Leukemia, ZNF384 rearrangement (13); B-cell Acute Lymphoblastic Leukemia, ZNF384 rearrangement like (1); T-cell Acute Lymphoblastic Leukemia, BCL11B rearrangement (2); T-cell Acute Lymphoblastic Leukemia, HOXA rearrangement (9); T-cell Acute Lymphoblastic Leukemia, NOS (18); T-cell Acute Lymphoblastic Leukemia, SET-NUP214 (2); T-cell Acute Lymphoblastic Leukemia, TAL1 rearrangement (2); T-cell Acute Lymphoblastic Leukemia, TLX3 rearrangement (5)
Case Tumor Site
Not Reported (735)
Number of Samples
735
Sample Assay Method
RNA Sequencing (2,220); Whole Exome Sequencing (112); Whole Genome Sequencing (252)
Additional Data Elements
DATA REPOSITORY
Published In
https://doi.org/10.1038/ng.2532;https://doi.org/10.1056/nejmoa1403088;https://doi.org/10.1038/ng.3909
SAMPLE TYPE
Diagnosis (735);  
Charts
Male (425); Female (310)
425Male